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testing

 
   
 



Indication & Dosage
 
 
Subcutaneous
CHRONIC MYELOID LEUKAEMIA
Adult:  4-5 million units/m2 daily; continue at the max tolerated dose to maintain remission.
Max Dosage:   4-10 million units/m2 daily.
 
Subcutaneous
FOLLICULAR LYMPHOMA
Adult:  As an adjunct to chemotherapy: 5 million units 3 times wkly for 18 mth.
 
Subcutaneous
CARCINOID TUMOURS
Adult: 3-9 million units (usually 5 million units) 3 times wkly. Advanced disease: 5 million units daily.
 
Subcutaneous
MULTIPLE MYELOMA
Adult: Maintenance dose following chemotherapy induction: 3 million units/m2 3 times wkly.
 
Parenteral
CHRONIC ACTIVE HEPATITIS B
Adult: 5-10 million units IM/SC 3 times wkly for 4-6 mth, or 5 million units daily for 16 wk.
 
Parenteral
CHRONIC HEPATITIS C
Adult: 3 million units IM/SC 3 times wkly for 6-12 mth (depending on genotype) when used with ribavirin, or for 6-18 mth (up to 24 mth) when used as monotherapy.
 
Parenteral
AIDS-RELATED KAPOSI'S SARCOMA
Adult: 30 million units/m2 IM/SC 3 times wkly.
 
Parenteral
HAIRY-CELL LEUKAEMIA
Adult:  2 million units/m2 IM/SC 3 times wkly for up to 6 mth or more.
 
Parenteral
MELANOMA
Adult:  Initially, 20 million units/m2 daily for 5 days each wk for 4 wk by IV
 
Injection
CONDYLOMATA ACUMINATA
Adult: Inject 1 million units into each lesion 3 times wkly for 3 wk; repeat after 12-16 wk as needed. Max: 5 lesions per treatment course.
   
Precautions History of pulmonary disease (e.g. COPD) or DM prone to ketoacidosis. Coagulation disorders or severe myelosuppression. Monitor patients with history of MI and/or arrhythmic disorders. Preexisting or history of psychiatric disorder, particularly depression. Poorly controlled thyroid abnormalities. Perform ophthalmological exam on patients with preexisting ophthalmologic disorders (e.g. diabetic or hypertensive retinopathy). Monitor WBC count in myelosuppressed patients and in those receiving other myelosuppressive agents. Preexisting psoriasis. May impair ability to drive or operate machinery. Pregnancy and lactation.
   
Potentially Life-threatening 
Adverse Drug Reactions
Flu-like symptoms; alopecia; hypersensitivity reactions; nausea; anorexia; myelosuppression; lethargy; ocular side effects; depression; CV problems; nephrotoxicity; hypertriglyceridaemia; thyroid abnormalities; hyperglycaemia; psoriasiform rash; confusion; coma; seizures.
   
Adverse Drug Reactions Hepatotoxicity, pulmonary infiltrates, pneumonitis and pneumonia, autoimmune diseases.
   
Interactions Reduces clearance of theophylline. Enhanced myelosuppression with other myelosuppressive drugs (e.g. zidovudine).
   
   
 

 

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